In addition, the American Geriatrics Society (Recommendations 2015), has also recommended avoiding NSAIDs in older patients because, in addition to their gastrointestinal toxicity, they can induce water retention and heart failure. Thus, NSAIDs administration should be avoided particularly on a continuous basis, and alternatives should be proposed. The risk of renal insufficiency is particularly high in patients with pre-existing renal disease and in patients that take NSAIDs chronically. Renal insufficiency is associated with high mortality. This is partly due to the high prevalence of chronic diseases in older people, especially diabetes, and cardiovascular diseases. Įpidemiological studies have shown an increasing incidence of renal insufficiency with age, particularly after 70 years. Moreover, these drugs have been linked to cartilage degradation. On the other hand, these prescriptions increase the risk of severe side effects. This aim explains the increase in prescriptions for nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesics. Management strategies of osteoarthritis in older individuals aim to preserve the best possible functional independence and quality of life. Moreover, the pain associated with knee osteoarthritis increases dramatically with age. Its prevalence was estimated at 15% in women aged 70 years and 30% after age 85. Knee osteoarthritis occurs rarely before age 30 but it becomes very common after age 60 years. Īnother musculoskeletal disturbance associated with aging is knee pain. Low back pain is relatively supportable during walking, but it becomes increasingly severe during prolonged sitting, more troublesome during physical activities and more disabling during prolonged standing. It can be severe (56 ± 20 mm on a visual analogue scale of pain between 0 and 100 mm) in older patients (mean age 73.6 years) and it is sometimes quite disabling. Īmong musculoskeletal disturbances associated with age, low back pain is common.
Consequently, the prescriptions cause disturbances in postural balance and alterations in consciousness which lead indirectly to more frequent falls and loss of autonomy.
These drugs are given at increasingly powerful doses as the condition becomes more severe. Īs with younger patients, older patients with osteoarthritis are managed with anti-inflammatory drugs and analgesics. Its cardinal symptoms are pain and the associated reduction of physical capacity. The prevalence of osteoarthritis also increases to above 37% after age 60 years. The functional degradation that accompanies aging is aggravated by osteoarthritis. These conditions lead to a high risk of drug-drug interactions and undesirable effects. With age, managing comorbidities becomes increasingly more complicated and drug prescriptions grow in number (3.6 times more than in young individuals). When ageing, although the individual variations are important, our functional capacities decrease including cardiovascular, cerebrovascular and musculoskeletal functions as co-morbidities evolve. These initial results must be confirmed in Painful osteoarthritis, particularly in older patients that are fragile due toĬomorbidity and polymedication. Conclusion: In conclusion, our results suggested thatįlexofytol ®, may be useful in the management of We observed no significantĪdverse effects. Weeks of treatment and up to 3 months of treatment without impacting renalįunction, metabolic parameters or coagulation tests.
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A series of quality of life parameters improved within the first 6 Pain improved by 50% (p = 0.0002) and functional disability improved by 33% (p =Ġ.0075). Results: Patients withįlexofytol ®, showed significant improvement: Wilcoxon-Mann-Withney non-parametric tests. In particular, weĮvaluated renal function, diabetes parameters and coagulation tests. Adverse effects and drug interactions ofįlexofytol ®, were evaluated. TheĮffects of Flexofytol ®, were evaluated at 0, 6Īnd 12 weeks with visual analog scales for pain and disability and the SF-12 Renal insufficiency (71%), or they were taking anticoagulants (35%). These patients were initially weakened by diabetes (48%) and/or That were treated with Flexofytol for painful osteoarthritis of the knee or Study included 31 patients over age 70 years (medianage: 77 years, range 71 - 81) Patients and Methods: This retrospective observational Risks of Flexofytol ®, in an older population Therefore, we aimed to assess the benefits and However, in older patients, indications for treatment might be limited byĬomorbidity and polymedication. Osteoarthritis includes several extracts of Curcuma including Flexofytol ®,Ī bio-optimized extract of Curcuma longa. Introduction: Currently, the therapeutic arsenal of
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